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nuri77 The mechanism of Nur77 regulating cell survival and apoptosis in CNS. Nur77 mediates cell apoptosis through caspase, endoplasmic reticulum stress, and mitochondrial autophagy, while. The role of Nur77 in celastrol-induced mitophagy was illustrated by reduction of autophagic mitochondria (from 12.20 to 0.02%) and diminished COXII degradation in HeLa

nuri77 slot, The expression of nur77 gene and Nur77 are induced at 0–4 hr after 10 µM forskolin treatment in PC12 cells. (A) PC12 cells were treated with 10 μM forskolin.nur77.